Présentation
Ludovic Fillon
Ingénieur de recherche en bio statistique et neuro imagerie
Ingénieur de Recherche en traitement d'images cérébrales multimodales au sein de l'équipe Image@Imagine (INSERM UMR 1163 Institut Imagine) et de la plateforme 3T recherche du Service de Radiologique Pédiatrique du Pr. Nathalie Boddaert.
Missions
- Mise en place de protocole de recherche,
- Collecte et gestion des données,
- Analyse et traitement des images,
- Développement d'algorithmes et logiciels de traitement d'images, visualisation et statistiques,
- Publication et valorisation des travaux de recherche et de l'équipe,
- Administrateur du parc informatique de l'équipe,
- Web-référent de l'équipe.
Co-auteur des publications suivantes (Image@Imagine)
Vinçon-Leite et al., "Identifying interindividual variability of social perception and associated brain anatomical correlations in children with autism spectrum disorder using eye-tracking and diffusion tensor imaging MRI (DTI-MRI)"
(2024) Cerebral Cortex
----- #TroubleSpectreAutisme #DTI #Eye-tracking #Pédiatrie
Dangouloff-Ros et al., "Abnormal Spontaneous Blood Oxygenation Level Dependent Fluctuations in Children with Focal Cortical Dysplasias: Initial findings in surgically confirmed cases"
(2023) Neuropediatrics
----- #Epilepsie #DysplasieCorticaleFocale #IRMf #ReHo #Pédiatrie
Boisgontier et al., "Zolpidem’s paradoxical restorative action: A case report of functional brain imaging"
(2023) Frontiers in Neuroscience
----- #Zolpidem #IRMfRepos #Connectivité #ASL-MRI #CaseReport #Pédiatrie
Dangouloff-Ros ; Fillon et al., "Preoperative Detection of Subtle Focal Cortical Dysplasia in Children by Combined ASL, VBM, EEG-fMRI, Resting-State Regional Homogeneity, and FDG-PET"
(2023) Neurosurgery
----- #Epilepsie #DysplasieCorticaleFocale #Multi-modalité #Pédiatrie
Rutten ; Fillon et al., "The longitudinal evolution of cerebral blood flow in children with tuberous sclerosis assessed by arterial spin labeling magnetic resonance imaging may be related to cognitive performance"
(2023) European Radiology
----- #ScléroseTubéreuseDeBourneville #ASL-MRI #Pédiatrie
Eisermann & Fillon et al., "Periodic electroencephalographic discharges and epileptic spasms involve cortico-striatal-thalamic loops on Arterial Spin Labeling Magnetic Resonance Imaging"
(2022) Brain Communications
----- #SpasmesInfantiles #Striatum #Thalamus #ASL-MRI #Pédiatrie
Pouliquen ; Fillon et al., "Arterial Spin-Labeling Perfusion Imaging in the Early Stage of Sturge-Weber Syndrome"
(2022) American Journal of Neuroradiology
----- #Sturge-Weber #ASL-MRI #Pédiatrie
Boisgontier et al., "A CBF decrease in the left supplementary motor areas: New insights into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI"
(2021) Journal of Cerebral Blood Flow and Metabolism
----- #Médulloblastome #Mutisme #ASL-MRI #Pédiatrie
Lemaître et al., "Rest functional brain maturation during the first year of life"
(2021) Cerebral Cortex
----- #DéveloppementTypique #MaturationCérébrale #ASL-MRI #Pédiatrie
Coez ; Fillon et al., "Arterial Spin Labeling brain MRI study to evaluate the impact of deafness on cerebral perfusion in 79 children before cochlear implantation"
(2021) NeuroImage Clinical
----- #Surdité #ASL-MRI #Pédiatrie
Blauwblomme et al.,"Complete hemispherotomy leads to lateralized functional organization and lower level of consciousness in the isolated hemisphere"
(2020) Epilepsia Open
----- #Hemispherotomie #Epilepsie #ASL-MRI #IRMf #Pédiatrie
Vinçon-Leite et al., "Neural basis of interindividual variability in social perception in typically developing children and adolescents using diffusion tensor imaging"
(2020) Scientific Reports
----- #DéveloppementTypique #PerceptionSociale #DTI #Eye-Tracking #Pédiatrie
Rechtman et al., "Posterior fossa arachnoid cyst in a pediatric population is associated with social perception and rest cerebral blood flow abnormalities"
(2020) Cerebellum
----- #KysteFossePostérieure #PerceptionSociale #ASL-MRI #Eye-Tracking #Pédiatrie
Boisgontier et al., "Anatomical and functional abnormalities on MRI in kabuki syndrome"
(2019) NeuroImage Clinical
----- #SyndromeKabuki #ASL-MRI #Pédiatrie
(mis à jour le 21 Mars 2025)
Ressources & publications
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form ...
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Journal (source)J. Exp. Med.
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.
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Journal (source)Nat. Med.
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 a...
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Journal (source)Sci Immunol
Chronic mucocutaneous candidiasis and connective tissue disorder in humans wi...
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Journal (source)Open Forum Infect Dis
Candidate Predisposition Variants in Kaposi Sarcoma as Detected by Whole-Geno...
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Journal (source)Nat. Med.
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 a...
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Journal (source)Front Genet
Identification of an Endoglin Variant Associated With HCV-Related Liver Fibro...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form ...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by nega...
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Journal (source)J. Exp. Med.
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti...
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Journal (source)J. Exp. Med.
Severe influenza pneumonitis in children with inherited TLR3 deficiency.
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Journal (source)J. Exp. Med.
Inherited IL-18BP deficiency in human fulminant viral hepatitis.
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Journal (source)Curr. Opin. Immunol.
Human inborn errors of immunity to infection affecting cells other than leuko...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Blacklisting variants common in private cohorts but not in public databases o...
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Journal (source)Sci Immunol
Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous...
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Journal (source)Sci Immunol
Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23.
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Journal (source)J. Clin. Invest.
Rescue of recurrent deep intronic mutation underlying cell type-dependent qua...
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Journal (source)Hum. Mol. Genet.
A purely quantitative form of partial recessive IFN-γR2 deficiency caused by ...
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Journal (source)J. Exp. Med.
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficie...
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Journal (source)Nat. Immunol.
Disruption of an antimycobacterial circuit between dendritic and helper T cel...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Incomplete penetrance for isolated congenital asplenia in humans with mutatio...
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Journal (source)J. Exp. Med.
The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to...
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Journal (source)Sci Immunol
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT...
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Journal (source)J. Clin. Immunol.
Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacte...
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Journal (source)J. Clin. Invest.
Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.
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Journal (source)Cell
Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.
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Journal (source)Am. J. Med. Genet. A
Kaposi sarcoma, oral malformations, mitral dysplasia, and scoliosis associate...
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Journal (source)J. Am. Coll. Cardiol.
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis.
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Journal (source)J. Allergy Clin. Immunol.
Exome and genome sequencing for inborn errors of immunity.
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Journal (source)Elife
IRF4 haploinsufficiency in a family with Whipple's disease.
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Common homozygosity for predicted loss-of-function variants reveals both redu...
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Journal (source)J. Pediatr.
From Dysgammaglobulinemia to Autosomal-Dominant Activation-Induced Cytidine D...
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Journal (source)Science
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19.
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Journal (source)Science
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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Journal (source)Nat Genet
Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syn...
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Journal (source)J Exp Med
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever...
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Journal (source)Nat Genet
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and...
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Journal (source)Hum Mutat
A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesyl...
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Journal (source)J Allergy Clin Immunol
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndr...
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Journal (source)J Pediatr
From Dysgammaglobulinemia to Autosomal-Dominant Activation-Induced Cytidine D...
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Journal (source)Sci Immunol
Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark o...
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Journal (source)Sci Immunol
Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark o...
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Journal (source)Sci Immunol
Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark o...
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Journal (source)Nat Med
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
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Journal (source)Med (N Y)
A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisyst...
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Journal (source)Nature
Human genetic and immunological determinants of critical COVID-19 pneumonia.
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Journal (source)J Exp Med
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I I...
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Journal (source)J Allergy Clin Immunol
Epithelial barrier dysfunction in desmoglein-1 deficiency.
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Journal (source)J Exp Med
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus an...